From cis-4-(2-Hydroxynaph-3-yl)-2-oxobut-3-enoate to 3-Hydroxy-2-naphthoate

Graphic of the reaction.

Medline reference

EVANS WC, FERNLEY HN, GRIFFITHS E. Biochem J (1965) 95: 819-31.

Search Medline for 3-hydroxy-2-naphthoate.

7 citations on September 14, 2009.

                                cis-4-(2-Hydroxynaph-3-yl)-2-oxobut-3-enoate                                 
                                                      |
                                                      |  H2O
         cis-4-(2-hydroxynaph-3-yl)-2-oxobut-3-enoate | /
                                   hydratase-aldolase |/
                                              4.1.2.- |
                                                      |\
                                               ExPASy | \
                                                      |  Pyruvate
                                                      v
                                         [3-Hydroxy-2-napthaldehyde]                                         
                                                      |
                                                      |  H2O
                                                      | /
                                                      |/
                                                      |
                                                      |\
                                                      | \
                                                      |  2H+ + 2e-
                                                      v
                                           3-Hydroxy-2-naphthoate                                            

UM-BBD Biotransformation rules in accord with this reaction:

2-Oxo-3-enoate-4-benzenoid -----> Pyruvate + Benzaldehyde derivative (bt0047)

Aldehyde -----> Carboxylate (bt0003)

Page Author(s): Robyn Geldner
May 17, 2006 Contact Us

This is the UM-BBD reaction, reacID# r1105.
It was generated on November 24, 2009 11:09:55 PM CST.

© 2009, University of Minnesota.