From 3-Chloro-cis,cis-muconate to 4-Methylenebut-2-en-4-olide

Graphic of the reaction.
Medline reference: Helin S, Kahn PC, Guha BL, Mallows DG, Goldman A. J Mol Biol (1995) 254(5): 918-41.
Search Medline for muconate cycloisomerase.: 89 citations on June 26, 2008.

     3-Chloro-cis,cis-muconate     
                 |
                 |
        muconate |
  cycloisomerase |
         5.5.1.1 | Search GenBank, 135 hits on Sep. 22, 2008
           Kyoto |\
          ExPASy | \
                 |  Cl^- + CO₂
                 v
    4-Methylenebut-2-en-4-olide

Generate a pathway starting from this reaction.

UM-BBD Biotransformation rules in accord with this reaction:: 3-Halo-cis,cis-muconate derivative -----> cis-4-Carboxymethylenebut-2-en-4-olide derivative (bt0206); 2- or 3- substituted Carboxylate -----> RH + CO₂ (bt0051)

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Page Author(s): Eva Young
August 14, 2005 Contact Us

This is the UM-BBD reaction, reacID# r0284.
It was generated on November 24, 2009 7:15:31 AM CST.

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