From p-Toluate to 4-Methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid

Graphic of the reaction.

Medline reference

Walsh TA, Ballou DP, Mayer R, Que L Jr. J Biol Chem (1983) 258(23): 14422-7.

Search Medline for benzoate 1,2-dioxygenase.

36 citations on October 20, 2008.

                           p-Toluate                           
                               |
                               |  NAD(P)H + O2 + H+
                      benzoate | /
               1,2-dioxygenase |/
                    1.14.12.10 | Search GenBank, 7 hits on Sep. 22, 2008
                         Kyoto |\
                        ExPASy | \
                               |  NAD(P)+
                               v
  4-Methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid   

UM-BBD Biotransformation rules in accord with this reaction:

1-carboxy-2-unsubstituted Aromatic -----> 1-Carboxy-1,2-dihydroxy-2-hydroaromatic (bt0368)

Page Author(s): Mili Jeon and Stephen Stephens
August 14, 2005 Contact Us

This is the UM-BBD reaction, reacID# r0178.
It was generated on November 24, 2009 10:04:19 PM CST.

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