From 2-Hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate to 2-Oxopent-4-enoate and Salicylate

Graphic of the reaction.

Medline reference

Bunz PV, Falchetto R, Cook AM. Biodegradation (1993) 4(3): 171-8.

Search Medline for 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase.

24 citations on June 26, 2008.

                  2-Hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate                  
                                            |
                                            |  H2O
  2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate | /
                                  hydrolase |/
                                    3.7.1.8 | Search GenBank, 64 hits on Jun. 27, 2008
                                      Kyoto |\
                                     ExPASy | \
                                            |  H+
                                            v
                             2-Oxopent-4-enoate + Salicylate                             

UM-BBD Biotransformation rules in accord with this reaction:

1-Aldo/keto-2,4-diene-5-ol -----> Carboxylate + 1-ene-4-one (bt0040)

Page Author(s): Anthony Ouellette and Ryan McLeish
December 15, 2005 Contact Us

This is the UM-BBD reaction, reacID# r0028.
It was generated on November 24, 2009 10:09:22 PM CST.

© 2009, University of Minnesota.