3-Methhylquinoline can be found in groundwater near landfills containing azaarene contaminated wastes, near creosote wood preservation facilities, in aquifers affected by fossil fuel processing activities and in shale oil. This compound is a known carcinogen causing various health effects and environmental damage, thus its environmental fate and biodegradation is important ( Schach et al., 1993). Comamonas testosteroni 63, from activated sludge, is known to degrade 3-methylquinoline to 2,5,6-trihydroxy-3-methylpyridine. This compound is degraded further to unknown products.
The following is a text-format 3-methylquinoline pathway map. An organism which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (15k) format.
3-Methylquinoline
Comamonas testosteroni 63
|
|
| quinoline 2-oxidoreductase
|
|
v
3-Methyl-2-oxo-1,2-dihydroquinoline
/ \
/ \
3-methyl-2-oxo-1,2- / \ 2-oxo-1,2-dihydroquinoline
dihydroquinoline / \ 5,6-dioxygenase
6-monooxygenase / \
/ \
/ \
6-Hydroxy-3-methyl- 5,6-Dihydrodiol-3-methyl-
2-oxo-1,2-dihydroquinoline 2-oxo-1,2-dihydroquinoline
\ /
6-hydroxy-3-methyl-2-oxo- \ / 5,6-dihydrodiol-3-methyl-
1,2-dihydroquinoline \ / 2-oxo-1,2-dihydroquinoline
5-monooxygenase \ / dehydrogenase
\ /
\ /
5,6-Dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline
|
|
| 5,6-dihydroxy-3-methyl-
| 2-oxo-1,2-dihydroquinoline
| dioxygenase
|
v
3-Methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon
|
|
| 3-methyl-5-hydroxy-6-
| (3-carboxy-3-oxopropenyl)-1H-2-
| pyridon hydratase aldolase
|
v
2,5,6-Trihydroxy-3-methylpyridine
Page Author(s): Sandy Etienne
April 25, 2008 Contact Us
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